Packrat
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Packrat for OSX is an offline editor for Backpack from 37signals that makes use of their API. The reason I mention it is because the author, Rod Schmidt, gave me service above and beyond when I ran into some bugs with the program. The bugs will be fixed up in the next release and it should become a great tool for keeping organized, online and off! Additional plug: I’ve been using Backpack daily and it’s worth every penny of the $5/month I spend on it. 
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